circRNA basic information
circBase ID: -
Name: rno_circ_Itch
Synonym: circRNA4426 / circRNA 4426
Host Gene: Itch
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0043797
MONDO name: spinal cord injury
Disease details: suprasacral spinal cord injury / SSCI
Disease DO ID:
 -
Disease MeSH ID:
 D013119
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Rat
Species details: Rattus norvegicus
Tissue specimen:

bladder tissues
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: Itch
Associated microRNA: -
Biological function: may be involved in organ fibrosis and inflammatory processes in SSCI-induced NB
Molecular mechanism: Predicted involvement via circRNA-miRNA-mRNA (ceRNA) networks; discussion relates circRNA4426 to circ-Itch literature but no circRNA4426-specific miRNA axis experimentally validated in this study.
Biological pathway or process:

inflammation (other); fibrosis (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA4426 (host gene Itch) is significantly down-regulated in rat bladder tissue after SSCI and is qRT-PCR validated. The authors suggest it may be involved in fibrosis/inflammation in SSCI-induced neurogenic bladder, but do not experimentally establish a circRNA4426-specific miRNA/mRNA axis.
Confidence score:

0.4997
Other information
Title:

Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.

Journal: PeerJ
Published: 2023
PubMed ID: 37744239
Study type:

combined biological and bioinformatics study
Data availability: GSE227447; Supplemental File
Code availability: -