circRNA basic information
circBase ID: hsa_circ_0000144
Name: hsa_circ_SLAMF6
Synonym: circ_0000144
Host Gene: SLAMF6
Genomic location(hg19): chr1:160472466-160472794:+
Genomic location(hg38): chr1:160502676-160503004:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; paired non-carcinoma tissue; serum; peripheral blood
Cell lines:

SKOV3; ES-2; OVCAR3; IOSE80
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ELK3
Associated microRNA: miR-610
Biological function: Promotes ovarian cancer cell proliferation, migration, invasion, and tumorigenesis.
Molecular mechanism: Acts as a miRNA sponge for miR-610 to regulate ELK3 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ_0000144 expression was associated with shorter OS and DFS; proposed as diagnostic and prognostic biomarker.
Description:

hsa_circ_0000144 is upregulated in ovarian cancer tissues, serum, and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-610 to increase ELK3 expression, and high circ_0000144 expression is associated with worse OS/DFS.
Confidence score:

0.8496
Other information
Title:

Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.

Journal: Journal of ovarian research
Published: 2022
PubMed ID: 36243865
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author upon reasonable request.
Code availability: -