| Expression pattern: |
UP |
| Associated gene: |
CHD7 |
| Associated microRNA: |
miR-885-3p |
| Biological function: |
circ-SFMBT2 promotes gastric cancer cell viability, colony formation, migration, invasion, oxidative stress and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ-SFMBT2 functions as a ceRNA by sponging miR-885-3p to upregulate CHD7 and activate the Wnt/beta-catenin signaling pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ-SFMBT2 may be an ideal biomarker for gastric cancer treatment. |
| Description: |
circ-SFMBT2 is up-regulated in gastric cancer tissues and cells. It promotes malignant phenotypes and tumor growth by sponging miR-885-3p, thereby increasing CHD7 expression and activating Wnt/beta-catenin signaling. Knockdown of circ-SFMBT2 suppresses gastric cancer cell viability, colony formation, migration, invasion and oxidative stress while inducing apoptosis. |
| Confidence score: |
0.8006 |