| Expression pattern: |
DS |
| Associated gene: |
ITCH, Ago2, Wnt/beta-catenin pathway, Bcl-2, Bax, cleaved PARP, beta-catenin, c-Myc, CCND1 |
| Associated microRNA: |
miR-1252 |
| Biological function: |
hsa_circ_0043256 inhibits NSCLC cell proliferation, induces apoptosis, mediates cinnamaldehyde-induced apoptosis, and contributes to Wnt/beta-catenin pathway suppression. |
| Molecular mechanism: |
hsa_circ_0043256 acts as a miR-1252 sponge, relieves miR-1252-mediated repression of ITCH, upregulates ITCH, and thereby inhibits the Wnt/beta-catenin pathway in the anti-tumor response to cinnamaldehyde. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); apoptosis (promotes); proliferation (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
The hsa_circ_0043256/miR-1252/ITCH axis provides a novel insight into lung cancer therapy and implies the potential of cinnamaldehyde as a therapeutic agent against NSCLC. |
| Description: |
This study identifies hsa_circ_0043256 as a cinnamaldehyde-responsive circular RNA in NSCLC models. hsa_circ_0043256 inhibits proliferation and promotes apoptosis by acting as a miR-1252 sponge, increasing ITCH expression and suppressing Wnt/beta-catenin signaling. Its knockdown weakens cinnamaldehyde-induced apoptosis and tumor-growth inhibition, supporting its role in cinnamaldehyde-mediated anti-tumor activity. |
| Confidence score: |
0.7283 |