| Expression pattern: |
UP |
| Associated gene: |
GPRC5A, Ago2 |
| Associated microRNA: |
miR-623 |
| Biological function: |
Promotes gastric cancer cell proliferation, colony formation, migration, invasion and glutaminolysis, and inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miR-623 sponge, relieving miR-623-mediated repression of GPRC5A and thereby promoting GC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Elevated circ_0000144 expression was correlated with poor cell differentiation, advanced TNM stage and lymph node metastasis; elevated expression predicted a poor clinical outcome of GC patients. |
| Description: |
circ_0000144 is up-regulated in gastric cancer and promotes malignant phenotypes and glutaminolysis while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-623 to up-regulate GPRC5A, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.6831 |