circRNA basic information
circBase ID: hsa_circ_0008433
Name: hsa_circ_PDE4B
Synonym: -
Host Gene: PDE4B
Genomic location(hg19): chr1:66378927-66384518:+
Genomic location(hg38): chr1:65913244-65918835:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005291
MONDO name: brain aneurysm
Disease details: intracranial aneurysm
Disease DO ID:
 10941
Disease MeSH ID:
 D002532
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

IA walls; superficial temporal arteries (STAs); peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MMP2
Associated microRNA: hsa-miR-181c-5p, hsa-miR-181b-5p
Biological function: Associated with vascular injury via regulation of inflammatory gene MMP2 in IA through ceRNA.
Molecular mechanism: ceRNA (miRNA sponge) mechanism regulating MMP2 via hsa-miR-181c-5p and hsa-miR-181b-5p.
Biological pathway or process:

ceRNA regulation (other); invasion (promotes); inflammation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Differentially expressed in peripheral blood of IA patients; potential noninvasive diagnostic biomarker with ROC AUC 0.8022.
Description:

hsa_circ_0008433 is up-regulated in intracranial aneurysm tissues and is implicated in vascular injury by regulating MMP2 through a ceRNA mechanism (sponging hsa-miR-181c-5p and hsa-miR-181b-5p). It is differentially expressed in peripheral blood and shows diagnostic potential by ROC analysis.
Confidence score:

0.5963
Other information
Title:

High-Throughput Data Reveals Novel Circular RNAs via Competitive Endogenous RNA Networks Associated with Human Intracranial Aneurysms.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2019
PubMed ID: 31254341
Study type:

combined biological and clinical study
Data availability: -
Code availability: -