| Expression pattern: |
UP |
| Associated gene: |
IL-7 |
| Associated microRNA: |
miR-338-5p |
| Biological function: |
promotes cisplatin resistance (chemoresistance) and decreases cisplatin-induced apoptosis in HCC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_HMGCS1 sponges miR-338-5p to upregulate IL-7, contributing to cisplatin resistance |
| Biological pathway or process: |
chemoresistance (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes); immune regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; RNA-seq |
| Clinical significance: |
circ_HMGCS1 might be a valuable biomarker or target for HCC |
| Description: |
circ_HMGCS1 is up-regulated in cisplatin-resistant HCC cell lines and promotes chemoresistance by reducing cisplatin-induced apoptosis and sustaining proliferation. Mechanistically, it acts as a sponge for miR-338-5p to upregulate IL-7, forming a circ_HMGCS1/miR-338-5p/IL-7 axis that contributes to resistance and may relate to immune regulation via IL-7. |
| Confidence score: |
0.7884 |