| Expression pattern: |
UP |
| Associated gene: |
CDC25B |
| Associated microRNA: |
miR-585, miR-585-3p |
| Biological function: |
Promotes CRC cell proliferation, migration and invasion; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-585 to promote CDC25B expression; CDC25B overexpression rescues effects of hsa_circRNA_102958 silencing. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High hsa_circRNA_102958 expression is associated with advanced clinical stage, lymph node metastasis, and poor prognosis/low survival rate in CRC patients. |
| Description: |
hsa_circRNA_102958 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion and xenograft tumor growth by sponging miR-585 to de-repress CDC25B expression, and high expression predicts poorer patient survival. |
| Confidence score: |
0.7588 |