circRNA basic information
circBase ID: -
Name: hsa_circ_UBXN7
Synonym: cirUBXN7
Host Gene: UBXN7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker to distinguish malignant from benign pulmonary ground-glass nodules.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

A component of a 4-ncRNA plasma biomarker panel that distinguishes malignant from benign GGNs with AUC up to 0.88 in external validation.
Description:

cirUBXN7 is up-regulated in peripheral blood/plasma of patients with malignant pulmonary GGNs compared with benign GGNs and healthy controls. It was selected as one of four ncRNAs in a logistic-regression biomarker panel that improves diagnostic discrimination of malignant vs benign GGNs and was validated in internal and external cohorts.
Confidence score:

0.459
Other information
Title:

Biomarkers via liquid biopsy for distinguishing malignant from benign pulmonary ground-glass nodule.

Journal: iScience
Published: 2025
PubMed ID: 40822904
Study type:

combined biological and clinical study
Data availability: -
Code availability: https://github.com/liusjliusj/medical.git