| Expression pattern: |
DN |
| Associated gene: |
DDR2, SAT2 |
| Associated microRNA: |
hsa-miR-519e-5p, hsa-miR-516b-5p |
| Biological function: |
Associated with SMC dysfunction and vascular injury; regulates SMC-related genes (DDR2, SAT2) in IA via ceRNA. |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism regulating DDR2 and SAT2 via hsa-miR-519e-5p and hsa-miR-516b-5p. |
| Biological pathway or process: |
ceRNA regulation (other); mitochondrial function (unclear); apoptosis (unclear) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Differentially expressed in peripheral blood of IA patients; potential noninvasive diagnostic biomarker with ROC AUC 0.7544. |
| Description: |
hsa_circ_0072309 is down-regulated in intracranial aneurysm tissues and also shows consistent down-regulation in peripheral blood. It likely acts as a ceRNA by sponging hsa-miR-519e-5p and hsa-miR-516b-5p to regulate DDR2 and SAT2, implicating smooth muscle cell dysfunction and vascular injury, and it shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.5963 |