circRNA basic information
circBase ID: hsa_circ_0001756
Name: hsa_circ_HIPK2
Synonym: circHIPK2 / Circular HIPK2
Host Gene: HIPK2
Genomic location(hg19): chr7:139415730-139416814:-
Genomic location(hg38): chr7:139715931-139717015:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

mouse intestinal organoids
Cell lines:

HCT116; HEK293T; MC38
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-124-3p
Biological function: Inhibits cell migration and tumorigenesis; promotes cytokine expression (IL8, IL6, GM-CSF) induced by S. typhimurium; promotes proliferation and tumor growth when overexpressed.
Molecular mechanism: ceRNA mechanism: circHIPK2 sponges miR-124-3p, affecting cell migration and tumorigenesis.
Biological pathway or process:

migration (promotes); proliferation (promotes); metastasis (promotes); inflammation (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Transwell Assay; CCK8; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In S. typhimurium-infected CRC models, circHIPK2 (hsa_circ_0001756, from HIPK2) is down-regulated and functions as a ceRNA by sponging miR-124-3p. Reducing circHIPK2 suppresses migration, cytokine induction, and tumor growth, while circHIPK2 overexpression promotes proliferation/migration and increases tumor burden in a syngeneic mouse model.
Confidence score:

0.8324
Other information
Title:

Salmonella typhimurium downregulates circHIPK2 expression via CeRNA mechanism to inhibit cell migration and tumorigenesis.

Journal: Gut pathogens
Published: 2025
PubMed ID: 41046253
Study type:

combined biological and clinical study
Data availability: -
Code availability: -