circRNA basic information
circBase ID: hsa_circ_0106394
Name: hsa_circ_USP22
Synonym: circ_0106394
Host Gene: USP22
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

formalin-fixed paraffin-embedded cervical tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Progressively downregulated across stages; suggested tumor-suppressive role (hypothesized).
Molecular mechanism: not specified
Biological pathway or process:

proliferation (other); apoptosis (other); glycolysis (other)
Detected method:
S
Validation methods:

circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Stage-dependent downregulation across benign→precancer→cancer suggests potential biomarker relevance for progression monitoring.
Description:

circ_0106394 (USP22-associated) shows progressive downregulation across cervical disease stages and is the top signal in the three-way comparison, suggesting potential value for tracking progression. Proposed functional relevance (e.g., proliferation/apoptosis/metabolic reprogramming) is discussed without experimental validation.
Confidence score:

0.3991
Other information
Title:

Novel circRNA signatures in cervical cancer: implications for early detection and screening.

Journal: Biomarkers in medicine
Published: 2026
PubMed ID: 41715885
Study type:

combined biological and clinical study
Data availability: GSE102686; GSE107472
Code availability: -