| Expression pattern: |
UP |
| Associated gene: |
ANGPT2, Tie2, FAK, AKT |
| Associated microRNA: |
miR-518a-5p |
| Biological function: |
promotes angiogenesis, migration, invasion and metastasis in CRC |
| Molecular mechanism: |
ceRNA mechanism: circFAM169A sponges miR-518a-5p to increase ANGPT2, affecting Tie2 phosphorylation and activating FAK/AKT signaling to promote angiogenesis and metastasis |
| Biological pathway or process: |
angiogenesis (promotes); migration (promotes); invasion (promotes); metastasis (promotes); PI3K/AKT (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; RNA-seq; Microarray; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circFAM169A had diagnostic value to distinguish carcinoma and paracancerous tissues (AUC = 0.83) |
| Description: |
circFAM169A is up-regulated in CRC (including liver-metastasized CRC) and promotes angiogenesis and metastatic behaviors (migration/invasion) in vitro and in nude-mouse metastasis models. Mechanistically, it functions as a ceRNA by sponging miR-518a-5p to upregulate ANGPT2, impacting Tie2 phosphorylation and increasing p-FAK/p-AKT signaling to enhance angiogenesis. |
| Confidence score: |
0.8668 |