circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: hsa_circRNA_0001946
Host Gene: CDR1
Genomic location(hg19): chrX:139865339-139866824:+
Genomic location(hg38): chrX:140783174-140784659:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SIRT1, Wnt/beta-catenin signaling pathway
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circRNA_0001946 is significantly down-regulated in the serum of NSCLC patients compared to healthy volunteers.
Description:

hsa_circ_0001946 (from host gene CDR1) is down-regulated in serum of NSCLC patients versus healthy volunteers. It is PD-responsive in A549 cells (down-regulated after PD treatment) and was included as a key circRNA in the PD-related co-expression/regulatory network analysis.
Confidence score:

0.5841
Other information
Title:

Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.

Journal: Cells
Published: 2022
PubMed ID: 35954204
Study type:

combined biological and clinical study
Data availability: Please contact the corresponding author for all data requests.
Code availability: -