| Expression pattern: |
UP |
| Associated gene: |
FGFR2 |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
Promotes cardiac fibroblast activation and myofibroblast differentiation; promotes cardiac fibrosis and remodeling; knockdown attenuates/reverses fibrosis. |
| Molecular mechanism: |
ceRNA (miRNA sponge): circSMAD4 binds miR-671-5p in a sequence-specific manner, relieving miR-671-5p-mediated destabilization of FGFR2 mRNA, thereby increasing FGFR2 and promoting fibrotic activation. |
| Biological pathway or process: |
ceRNA regulation (promotes); fibrosis (promotes); proliferation (not specified) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Luciferase Reporter Assay; Transfection; In Vivo Animal Model; H&E Staining; Western Blot; Transwell Assay; Wound Healing Assay; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; ELISA; Tube Formation Assay; TUNEL; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circSMAD4 is up-regulated during cardiac fibrosis and promotes cardiac fibroblast activation/myofibroblast differentiation. It functions as a miRNA sponge for miR-671-5p, thereby increasing FGFR2 expression and driving fibrotic remodeling; silencing circSmad4 reduces fibrosis in ISP- and TAC-induced mouse models. |
| Confidence score: |
0.8072 |