circRNA basic information
circBase ID: hsa_circ_0001313
Name: hsa_circ_CCDC66
Synonym: circ-CCDC66 / circCCDC66
Host Gene: CCDC66
Genomic location(hg19): chr3:56626997-56628056:+
Genomic location(hg38): chr3:56592969-56594028:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; CRC tissues; corresponding normal tissues (NAT); adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NR4A3, ARRB1, SMAD4, CADM2, NKIRAS1, IQSEC1, EPHA7, ANKRD33B, ZBTB39, ZNF107, SLC29A2, GINS4, CCND1, POLQ, ENPP5
Associated microRNA: hsa-miR-4326, hsa-miR-146a-3p, hsa-miR-19a-5p, hsa-miR-19b-1-5p, hsa-miR-200a-3p, hsa-miR-3913-3p, hsa-miR-452-5p, hsa-miR-4773, hsa-miR-93-3p, hsa-miR-93-5p, hsa-miR-5186
Biological function: May play a role in CRC development, invasion, and metastasis; proposed as a blood-based diagnostic biomarker for CRC and colorectal polyps.
Molecular mechanism: ceRNA network (circ-CCDC66-miRNA-mRNA) predicted/constructed by bioinformatics; correlation analysis between circ-CCDC66 and network nodes.
Biological pathway or process:

Wnt/beta-catenin (other); Hippo/YAP (other); proliferation (other); metastasis (other); apoptosis (other); ceRNA regulation (other); immune regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Plasma circ-CCDC66 shows high diagnostic accuracy for CRC (AUC 0.920) and improves diagnostic efficacy when combined with CEA and CA19-9; plasma circ-CCDC66 levels are positively correlated with lymph node metastasis, nerve invasion, tumor size, and TNM staging.
Description:

Plasma circ-CCDC66 is up-regulated in colorectal polyps and colorectal cancer and shows strong diagnostic performance (AUC 0.920), further improved when combined with CEA and CA19-9. Bioinformatics analyses construct a circ-CCDC66-miRNA-mRNA (ceRNA) network suggesting potential involvement in CRC-related pathways and processes.
Confidence score:

0.5047
Other information
Title:

Exploring the diagnostic potential of plasma circ-CCDC66 in colorectal cancer.

Journal: Scientific reports
Published: 2025
PubMed ID: 40181128
Study type:

combined biological and clinical study
Data availability: GSE126094; GSE126093; GSE126092; 10.1038/s41598-025-95685-5
Code availability: -