circRNA basic information
circBase ID: hsa_circ_0035431
Name: hsa_circ_CGNL1
Synonym: -
Host Gene: CGNL1
Genomic location(hg19): chr15:57730182-57734676:+
Genomic location(hg38): chr15:57437984-57442478:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0010150
MONDO name: head and neck squamous cell carcinoma
Disease details: head and neck squamous cell carcinoma / HNSCC
Disease DO ID:
 5520
Disease MeSH ID:
 C535575
Disease NCIt ID:
 C34447
Disease ICD11 ID:
 -
Disease OMIM ID:
 275355
Species: Human
Species details: Homo sapiens
Tissue specimen:

HNSCC tissue; adjacent healthy tissue
Cell lines:

Hok; SCC25; HSC2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FUT6, CGNL1
Associated microRNA: hsa-miR-940
Biological function: May regulate FUT6 and CGNL1 expression by sponging hsa-miR-940, thus impacting the occurrence, development and prognosis of HNSCC.
Molecular mechanism: ceRNA (miRNA sponge) mechanism involving hsa-miR-940 to regulate FUT6 and CGNL1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNase R Treatment; RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

May impact the prognosis of HNSCC via the hsa_circ_0035431/hsa-miR-940/FUT6 and hsa_circ_0035431/hsa-miR-940/CGNL1 axes.
Description:

hsa_circ_0035431 is downregulated in HNSCC tissues and cell lines. The study proposes a ceRNA mechanism where hsa_circ_0035431 sponges hsa-miR-940 to regulate FUT6 and CGNL1, potentially influencing HNSCC progression and prognosis.
Confidence score:

0.5135
Other information
Title:

Integrated analysis of high‑throughput sequencing reveals the regulatory potential of hsa_circ_0035431 in HNSCC.

Journal: Oncology letters
Published: 2023
PubMed ID: 37664656
Study type:

combined biological and clinical study
Data availability: GSE190224
Code availability: -