circRNA basic information
circBase ID: hsa_circ_0008870
Name: hsa_circ_MAPK1
Synonym: circMAPK1
Host Gene: MAPK1
Genomic location(hg19): chr22:22160138-22162135:-
Genomic location(hg38): chr22:21805849-21807846:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

spinal cord; quadriceps; cortex; brainstem
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: MAPK1
Associated microRNA: -
Biological function: -
Molecular mechanism: circRNA/host-gene expression correlation (both spinal cord and quadriceps)
Biological pathway or process:

MAPK (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

circMAPK1 is progressively down-regulated in spinal cord during ALS progression in SOD1G93A mice and is also significantly down-regulated in sALS brain; its levels correlate with MAPK1 host gene expression in both spinal cord and quadriceps.
Confidence score:

0.5129
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

combined biological and clinical study
Data availability: GSE289637
Code availability: -