| Expression pattern: |
UP |
| Associated gene: |
RPA1, Cyclin D1, CDK4, phospho-RB, phospho-AKT |
| Associated microRNA: |
- |
| Biological function: |
promotes LUAD cell proliferation and metastasis; promotes tumor growth in vivo |
| Molecular mechanism: |
binds RPA1 protein and increases RPA1 protein level (post-transcriptional), elevating Cyclin D1 and CDK4 proteins to activate CDK4 signaling |
| Biological pathway or process: |
proliferation (promotes); metastasis (promotes); cell cycle (promotes); PI3K/AKT (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; RNA-seq; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
elevated circLIMK1-005 expression is associated with poor prognosis in LUAD patients |
| Description: |
circLIMK1-005 is up-regulated in LUAD tissues/cells, mainly localized in the nucleus, and its high expression associates with poor patient survival. It promotes LUAD proliferation, cell-cycle progression, migration/invasion, and tumor growth by binding RPA1, increasing RPA1 protein level, and activating Cyclin D1/CDK4 signaling (with AKT phosphorylation as a downstream readout). |
| Confidence score: |
0.8766 |