| Expression pattern: |
UP |
| Associated gene: |
MMP3 |
| Associated microRNA: |
miR-421 |
| Biological function: |
Promotes proliferation, migration, invasion and EMT in HCC cells; circSEC24A knockdown suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-421, thereby regulating MMP3 to modulate EMT and tumor progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
circSEC24A could represent a potential target for HCC patient treatment. |
| Description: |
circSEC24A (hsa_circ_0003528) is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration, invasion and EMT by sponging miR-421 and thereby relieving miR-421-mediated repression of MMP3; circSEC24A knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.742 |