| Expression pattern: |
UP |
| Associated gene: |
Wnt10b, beta-catenin, Ago2 |
| Associated microRNA: |
miR-885-3p |
| Biological function: |
promotes tumorigenesis, proliferation, colony formation and invasion of LAC cells |
| Molecular mechanism: |
circTUBGCP3 acts as a miRNA sponge for miR-885-3p, leading to activation of Wnt10b/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulation of circTUBGCP3 was associated with pathological stage and poor survival in patients with LAC; circTUBGCP3 was an independent prognostic factor. |
| Description: |
circTUBGCP3 is up-regulated in lung adenocarcinoma and functions as an oncogenic circRNA. It sponges miR-885-3p to derepress Wnt10b and activate Wnt10b/beta-catenin signaling, promoting proliferation and invasion and supporting tumor growth in xenografts. High circTUBGCP3 expression is associated with advanced pathological stage and poorer overall survival. |
| Confidence score: |
0.8742 |