circRNA basic information
circBase ID: hsa_circ_0000370
Name: hsa_circ_FLI1
Synonym: circ_0000370
Host Gene: FLI1
Genomic location(hg19): chr11:128628009-128651918:+
Genomic location(hg38): chr11:128758114-128782023:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
5672, 9256
Disease MeSH ID:
-
Disease NCIt ID:
C4978
Disease ICD11 ID:
-
Disease OMIM ID:
114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissue samples; paired adjacent tissue samples; tumor tissues of mice

Cell lines:

HCT116; SW480; SW620; NCM460

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: SIRT1, Ago2, FLI1
Associated microRNA: miR-502-5p
Biological function: Circ_0000370 promotes CRC cell proliferation, migration, invasion, metastasis and tumor growth, and inhibits apoptosis.
Molecular mechanism: Circ_0000370 acts as a ceRNA by sponging miR-502-5p, thereby relieving miR-502-5p-mediated suppression of SIRT1 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis

Clinical significance:

Circ_0000370 may be an attractive candidate target for CRC treatment.

Description:

Circ_0000370 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-502-5p to increase SIRT1 expression. The study suggests circ_0000370 may be a potential therapeutic target for CRC.

Confidence score:

0.8005

Other information
Title:

Circ_0000370 Plays an Oncogenic Role in Colorectal Cancer by Regulating the miR-502-5p/SIRT1 Axis.

Journal: Biochemical genetics
Published: 2024
PubMed ID: 37561331
Study type:

combined biological and clinical study

Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request; Supplementary material available at https:// doi. org/ 10. 1007/ s10528-023-10468-9
Code availability: -