circRNA basic information
circBase ID: hsa_circ_0001756
Name: hsa_circ_HIPK2
Synonym: CircHIPK2 / circ_00001756
Host Gene: HIPK2
Genomic location(hg19): chr7:139415730-139416814:-
Genomic location(hg38): chr7:139715931-139717015:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent non-tumor tissues; serum
Cell lines:

MDA-MB-231; MCF-7; HEK-293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRAF6, HIPK2
Associated microRNA: miR-584-5p
Biological function: Promotes breast cancer malignant progression, including proliferation, migration, invasion, tumor growth, and EMT.
Molecular mechanism: Acts as a miR-584-5p sponge (ceRNA) to regulate TRAF6, promoting EMT and tumor progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum hsa_circ_0001756 is elevated in BC patients and shows diagnostic value (ROC AUC), and is correlated with tumor size, age, lymph node metastases/metastasis state, and TNM stage; combination with CEA and CA15-3 improves diagnostic accuracy.
Description:

hsa_circ_0001756 (CircHIPK2) is up-regulated in breast cancer tissues/cells and promotes tumor growth, proliferation, migration, invasion and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-584-5p to upregulate TRAF6. Serum hsa_circ_0001756 is elevated in BC and has diagnostic value, especially combined with CEA and CA15-3.
Confidence score:

0.8556
Other information
Title:

Hsa_circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis.

Journal: Translational cancer research
Published: 2026
PubMed ID: 41674950
Study type:

combined biological and clinical study
Data availability: GSE182471; https://tcr.amegroups.com/article/view/10.21037/tcr-2025-1610/dss
Code availability: -