| Expression pattern: |
UP |
| Associated gene: |
RABL6 |
| Associated microRNA: |
miR-361-3p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion, metastasis and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
circTMC5 acts as a miR-361-3p sponge to up-regulate RABL6 expression, thereby promoting GC progression; the axis may influence tumor immune regulation. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; TUNEL; IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model; H&E Staining; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircTMC5 was associated with histological grade, pathological stage and T classification; high circTMC5 predicted lower survival, was an independent prognostic factor, and combined detection with CEA may improve GC diagnosis. |
| Description: |
circTMC5 is up-regulated in gastric cancer tissues, plasma and cell lines and predicts poorer survival. It promotes GC progression and metastasis by sponging miR-361-3p and increasing RABL6 expression, enhancing proliferation, migration and invasion while suppressing apoptosis. circTMC5 also has potential diagnostic and prognostic value, and its downstream RABL6-related effects may involve immune regulation. |
| Confidence score: |
0.8525 |