| Expression pattern: |
UP |
| Associated gene: |
SIRT1, Ago2, FLI1 |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
Circ_0000370 promotes CRC cell proliferation, migration, invasion, metastasis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0000370 acts as a ceRNA by sponging miR-502-5p, thereby relieving miR-502-5p-mediated suppression of SIRT1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0000370 may be an attractive candidate target for CRC treatment. |
| Description: |
Circ_0000370 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-502-5p to increase SIRT1 expression. The study suggests circ_0000370 may be a potential therapeutic target for CRC. |
| Confidence score: |
0.8005 |