circRNA basic information
circBase ID: hsa_circ_0087391
Name: hsa_circ_AGTPBP1
Synonym: circAGTPBP1
Host Gene: AGTPBP1
Genomic location(hg19): chr9:88284399-88327481:-
Genomic location(hg38): chr9:85669484-85712566:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer / PTC
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; adjacent normal thyroid tissues
Cell lines:

Nthy-ori 3-1; TPC-1; B-CPAP; KTC-1; K1; IHH-4
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOTCH1, Hes1, Jagged1
Associated microRNA: miR-34a-5p
Biological function: Promotes PTC cell proliferation/viability, migration, invasion, EMT and metastasis; promotes tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA by sponging miR-34a-5p, thereby releasing NOTCH1 and activating NOTCH signaling.
Biological pathway or process:

Notch (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); proliferation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Clinical Sample Validation
Clinical significance:

circAGTPBP1 expression was positively correlated with tumor size, lymph node metastasis, and TNM stage.
Description:

circAGTPBP1 is upregulated in papillary thyroid cancer and promotes proliferation, migration, invasion, EMT, metastasis, and in vivo tumor growth. It functions as a ceRNA that sponges miR-34a-5p to de-repress NOTCH1, thereby activating Notch signaling.
Confidence score:

0.852
Other information
Title:

circAGTPBP1 promotes the progression of papillary thyroid cancer through the notch pathway via the miR-34a-5p/notch1 axis.

Journal: iScience
Published: 2023
PubMed ID: 37622004
Study type:

combined biological and clinical study
Data availability: GSE237841
Code availability: -