| Expression pattern: |
UP |
| Associated gene: |
TCF4, MMP2, MMP9 |
| Associated microRNA: |
miR-137 |
| Biological function: |
Promotes trophoblast cell migration and invasion; serves as a noninvasive prenatal biomarker for PAS prediction. |
| Molecular mechanism: |
circZMYM4 functions through a ceRNA mechanism involving miR-137 and TCF4 to regulate trophoblast migration and invasion. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay; ROC Analysis |
| Clinical significance: |
circZMYM4 was upregulated in maternal blood and served as an effective predictive biomarker for PAS; AUC 0.85 individually and included in a combined model with AUC 0.91-0.92. |
| Description: |
circZMYM4 is upregulated in PAS placenta and maternal blood. It promotes trophoblast migration and invasion, likely through a circZMYM4/miR-137/TCF4 ceRNA-related mechanism, and shows noninvasive biomarker potential for prenatal PAS prediction. |
| Confidence score: |
0.8111 |