| Expression pattern: |
UP |
| Associated gene: |
E2F2 |
| Associated microRNA: |
hsa-miR-1294, hsa-miR-593-3p |
| Biological function: |
Promotes GC cell viability/proliferation, migration, invasion, angiogenic potential, and in vivo tumor growth; acts as an oncogenic exosomal circRNA. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA in exosomes, targeting miR-1294 and miR-593-3p to derepress E2F2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSTRBP expression is associated with distant metastasis, advanced TNM stage, and poorer overall survival in GC patients; may be a prognostic biomarker. |
| Description: |
circSTRBP is up-regulated in gastric cancer tissues/cells and enriched in GC-derived exosomes. It promotes GC proliferation/viability, migration, invasion, angiogenesis and xenograft tumor growth by sponging miR-1294 and miR-593-3p to increase E2F2 expression, and high circSTRBP correlates with poor overall survival. |
| Confidence score: |
0.8821 |