circRNA basic information
circBase ID: hsa_circ_0029803
Name: -
Synonym: Circ_0029803
Host Gene: hsa-miR-216b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SKIL
Associated microRNA: hsa-miR-216b-5p
Biological function: Circ_0029803 depletion retarded proliferation, migration, invasion, EMT and glycolysis of CRC cells in vitro as well as the tumor growth in vivo
Molecular mechanism: circ_0029803 could serve as hsa-miR-216b-5p sponge to regulate its expression, and hsa-miR-216b-5p knockdown reversed the inhibition of si-circ_0029803 on the malignant behaviors of CRC cells
Survival: -
Supported No.:
 1
Description:

Circ_0029803 knockdown hindered proliferation, migration, invasion, EMT, and glycolysis and promoted apoptosis in CRC cells by modulating the miR-216b-5p/SKIL axis.
Other information
Title:

Circ_0029803 serves as the sponge of miR-216b-5p to promote the progression of colorectal cancer by regulating SKIL expression.

Journal: World J Surg Oncol
Published: 2021/9/5
PubMed ID: 34479589