| Expression pattern: |
DN |
| Associated gene: |
HIPK3 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
Suppresses breast cancer tumorigenesis and reduces tamoxifen resistance; inhibits proliferation, invasion and migration; promotes apoptosis and tamoxifen sensitivity. |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA by directly binding miR-197-3p, thereby relieving miR-197-3p-mediated repression of HIPK3. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); chemoresistance (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
High hsa_circ_0025202 expression level is associated with histologic grade, lymph node metastasis, and more advanced tumor and node stage in breast cancer patients. |
| Description: |
hsa_circ_0025202 is down-regulated in breast cancer tissues and especially in tamoxifen-resistant breast cancer cells. Functionally, it suppresses malignant phenotypes and tamoxifen resistance by sponging miR-197-3p and thereby restoring HIPK3 expression, improving tamoxifen sensitivity in vitro and in xenograft tumors. |
| Confidence score: |
0.6833 |