| Expression pattern: |
UP |
| Associated gene: |
ZEB2, E-cadherin, vimentin, fibronectin, AGO2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes HCC cell migration, invasion, metastases and EMT progression |
| Molecular mechanism: |
circHIPK3 acts as a miR-338-3p sponge to induce ZEB2 expression and regulate EMT-associated proteins |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IF (Immunofluorescence); Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Survival Analysis |
| Clinical significance: |
higher circHIPK3 expression indicated relatively poor overall survival in HCC patients and may provide potential therapeutic targets for advanced HCC patients |
| Description: |
circHIPK3 is upregulated in HCC tissues and cell lines, and higher expression is associated with poorer overall survival. Functionally, circHIPK3 promotes HCC migration, invasion, EMT and lung metastasis. Mechanistically, it sponges miR-338-3p to increase ZEB2 expression and regulate EMT-associated proteins. |
| Confidence score: |
0.7791 |