| Expression pattern: |
UP |
| Associated gene: |
GDA mRNA |
| Associated microRNA: |
- |
| Biological function: |
Promotes AGS gastric cancer cell proliferation and invasion in vitro; candidate oncogene in gastric cancer. |
| Molecular mechanism: |
circRNA0138960 positively correlates with and regulates its parental gene GDA mRNA expression; the authors speculate that it may modulate parental gene expression transcriptionally. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circRNA0138960 showed diagnostic value for GC with an AUC of 0.647. |
| Description: |
hsa_circ_0138960/circRNA0138960 is significantly up-regulated in gastric cancer tissues and preferentially localized in the cytoplasm of AGS cells. Its knockdown suppresses AGS cell proliferation and invasion, and its expression positively correlates with GDA mRNA. It shows modest diagnostic value for GC based on ROC analysis. |
| Confidence score: |
0.7364 |