circRNA basic information
circBase ID: -
Name: hsa_circ_RHOT1
Synonym: circ-RHOT1 / circ-RHOT-1
Host Gene: RHOT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PDK2, E2F1, E2F3, SATB2, SMAD5, VEGFA, VEGFR2, TAZ, YAP, RRM2, ATM/ATR-CHK1 signal pathway, PI3K-AKT signaling pathway
Associated microRNA: miR-125a-3p, miR-125a, miR-326, miR-3666, miR-125a-5p
Biological function: Potential oncogenic role in CRC (discussed), and is up-regulated in CRC patient blood.
Molecular mechanism: Discussed as a miRNA sponge (ceRNA), potentially regulating CRC proliferation and invasion by sponging miR-125a, miR-326 and miR-3666.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); invasion (promotes); glycolysis (promotes); PI3K/AKT (other); Hippo/YAP (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circ-RHOT1 could be used as a diagnostic marker for CRC (AUC 83.6%, sensitivity 70%, specificity 95%).
Description:

circ-RHOT1 is significantly up-regulated in CRC patient blood compared with healthy controls and has diagnostic value. The discussion proposes that circ-RHOT1 may promote CRC proliferation and invasion by sponging miR-125a, miR-326 and miR-3666, thereby influencing downstream targets such as PDK2 and SATB2-related pathways.
Confidence score:

0.4187
Other information
Title:

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer.

Journal: Scientific reports
Published: 2023
PubMed ID: 37587156
Study type:

clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -