| Expression pattern: |
UP |
| Associated gene: |
ENO2, IGF2BP3 |
| Associated microRNA: |
miR-2110 |
| Biological function: |
promotes proliferation, migration and invasion; promotes cell cycle progression; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0074854 suppresses miR-2110, leading to upregulation of ENO2 and IGF2BP3 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0074854 expression is positively correlated with advanced clinicopathological features and predicts unfavorable prognosis/poorer overall survival in CRC |
| Description: |
In colorectal cancer, hsa_circ_0074854 is up-regulated in tissues and CRC cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation/migration/invasion, induces G0/G1 arrest, and increases apoptosis. Mechanistically, it is proposed to function via a ceRNA axis by suppressing miR-2110 and thereby increasing ENO2 and IGF2BP3 expression, with downstream associations to immune cell infiltration through these target genes. |
| Confidence score: |
0.6111 |