circRNA basic information
circBase ID: hsa_circ_0108830
Name: hsa_circ_RTTN
Synonym: CircRTTN
Host Gene: RTTN
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005105
MONDO name: melanoma
Disease details: melanoma
Disease DO ID:
 1909
Disease MeSH ID:
 D008545
Disease NCIt ID:
 C3224
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

melanoma tissues; adjacent normal tissues; benign nevi; mouse subcutaneous xenografts
Cell lines:

A-375; SK-MEL-2; HEMn; HUVECs
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EPHA2, MMP2, MMP9, ki-67
Associated microRNA: miR-890
Biological function: CircRTTN promotes melanoma cell proliferation, migration, invasion, angiogenesis and xenograft tumor growth, and inhibits apoptosis.
Molecular mechanism: CircRTTN functions as a ceRNA by sponging miR-890 to upregulate EPHA2 expression in melanoma.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

CircRTTN expression was analyzed for correlation with clinicopathological parameters of patients with melanoma, but no prognosis or diagnostic value was reported in the provided text.
Description:

CircRTTN/hsa_circ_0108830 is an up-regulated human circRNA derived from RTTN in melanoma tissues and cell lines. It promotes melanoma malignant behaviors including proliferation, migration, invasion, angiogenesis and tumor growth, while suppressing apoptosis. Mechanistically, circRTTN sponges miR-890 to increase EPHA2 expression, forming a circRTTN/miR-890/EPHA2 regulatory axis.
Confidence score:

0.8443
Other information
Title:

CircRTTN upregulates EPHA2 to aggravate the malignant process of melanoma via sponging miR-890.

Journal: Histology and histopathology
Published: 2024
PubMed ID: 37158505
Study type:

combined biological and clinical study
Data availability: Please contact the correspondence author for the data request.
Code availability: -