| Expression pattern: |
UP |
| Associated gene: |
associated target genes |
| Associated microRNA: |
miR-570-3p, miR-17-3p, miR-552-3p |
| Biological function: |
Potential diagnostic biomarker of liver cancer; potentially involved in tumor progression through competitive binding of miRNAs and predicted circRNA-miRNA-mRNA regulation. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving competitive binding of miR-570-3p, miR-17-3p, and miR-552-3p with downstream target genes. |
| Biological pathway or process: |
p53 signaling (other); angiogenesis (other); cell cycle (other); ceRNA regulation (other); proliferation (other); invasion (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circFUT8 could significantly distinguish liver cancer samples, with an AUC of 0.7575, and represents a potentially valuable diagnostic biomarker. |
| Description: |
circFUT8 was significantly up-regulated in liver cancer tissues and validated by qRT-PCR. The study predicted that circFUT8 may competitively bind miR-570-3p, miR-17-3p, and miR-552-3p to affect target genes, and ROC analysis suggested diagnostic biomarker potential. |
| Confidence score: |
0.5047 |