| Expression pattern: |
UP |
| Associated gene: |
RAB3D, Ago2 |
| Associated microRNA: |
miR-588 |
| Biological function: |
promotes OS cell viability, proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circECE1 functions as a ceRNA by sponging miR-588 to regulate RAB3D expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High expression of circECE1 was closely associated with advanced TNM stage, positive lymph node metastasis, and large tumor size |
| Description: |
circECE1 (hsa_circ_0002402), derived from ECE1, is up-regulated in osteosarcoma tissues and cells and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, circECE1 sponges miR-588 to de-repress RAB3D, forming a circECE1/miR-588/RAB3D ceRNA axis; circECE1 knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8172 |