| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-548p |
| Biological function: |
Promotes HCC cell viability, proliferation, migration and invasion, and inhibits apoptosis; acts as an oncogenic circRNA in HCC. |
| Molecular mechanism: |
circ_0008450 functions as a miRNA sponge for miR-548p, negatively regulating miR-548p and thereby facilitating HCC tumorigenic cellular phenotypes. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0008450 expression is associated with larger tumor size, more advanced TNM stage, and lower overall survival; circ_0008450 may serve as a prognostic biomarker for HCC. |
| Description: |
circ_0008450 is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ_0008450 promotes HCC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts at least partly by sponging and suppressing miR-548p. |
| Confidence score: |
0.7113 |