| Expression pattern: |
UP |
| Associated gene: |
FNDC1, HTRA1, IER5 L, IFIT2, NDUFA4L2, SERPINE1 |
| Associated microRNA: |
hsa-miR-765, hsa-miR-198, hsa-miR-125a-3 p, hsa-miR-486-5 p |
| Biological function: |
Promotes gastric cancer cell activity, proliferation, migration, and invasion. |
| Molecular mechanism: |
Predicted ceRNA mechanism; overexpressed hsa_circ_0004228 may competitively bind and sequester tumor-suppressive miRNAs, releasing oncogenic mRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); PI3K/AKT (other); p53 signaling (other); HIF-1 signaling (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay |
| Clinical significance: |
Potential prognostic biomarker and therapeutic target in gastric cancer. |
| Description: |
hsa_circ_0004228 was up-regulated in gastric cancer tissues and cell lines. Knockdown experiments showed that it promotes GC cell activity, proliferation, migration, and invasion, likely through a predicted ceRNA mechanism involving tumor-suppressive miRNAs and downstream mRNAs. |
| Confidence score: |
0.6719 |