circRNA basic information
circBase ID: hsa_circ_0020397
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: DOCK1
Genomic location(hg19): chr10:128768965-128926028:+
Genomic location(hg38): chr10:126970701-127127764:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tumors; normal tissues adjacent to the tumors
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN, TP53, SOX2, CDKN1A, MGMT, IGF2, CDK2, CCND2
Associated microRNA: hsa-mir-638, hsa-mir-665
Biological function: may have a major function in breast cancer via ceRNA network (miRNA sponging)
Molecular mechanism: ceRNA (miRNA sponging) regulatory mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circ_0020397 over-expression had an important association with a lack of vitamin D consumption.
Description:

hsa_circ_0020397 is up-regulated in breast cancer tissues versus adjacent normal tissues and is associated with lack of vitamin D consumption. The study proposes that it may function through predicted circRNA/miRNA/mRNA ceRNA networks involving miRNAs such as hsa-mir-638 and hsa-mir-665 and target mRNAs including PTEN and TP53.
Confidence score:

0.348
Other information
Title:

Altered Expression of hsa_circ_0001445 and hsa_circ_0020397 in Breast Cancer Representing Associations with BMI and Reproductive Factors.

Journal: Archives of Iranian medicine
Published: 2022
PubMed ID: 37543909
Study type:

combined biological and clinical study
Data availability: -
Code availability: -