| Expression pattern: |
UP |
| Associated gene: |
LASP1, AGO2 |
| Associated microRNA: |
miR-877-5p |
| Biological function: |
promotes proliferation, migration, invasion and stemness; inhibits apoptosis in LSCC cells |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-877-5p to upregulate LASP1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Western Blot; Annexin V/PI Flow Cytometry; Colony Formation Assay; Transwell Assay |
| Clinical significance: |
High circSLC7A11 expression is associated with advanced TNM stage and shorter overall survival in LSCC patients. |
| Description: |
circSLC7A11 is up-regulated in LSCC and its high expression correlates with advanced TNM stage and poorer overall survival. Functionally, circSLC7A11 promotes LSCC malignant phenotypes (proliferation, migration/invasion, stemness) and suppresses apoptosis by sponging miR-877-5p to increase LASP1. |
| Confidence score: |
0.7754 |