| Expression pattern: |
UP |
| Associated gene: |
EPSTI1 |
| Associated microRNA: |
miR-578 |
| Biological function: |
Relieves (attenuates) sevoflurane-induced suppression of breast cancer malignant behaviors by promoting proliferation, migration and invasion, and inhibiting apoptosis; partially reverses sevoflurane-induced tumor growth inhibition in vivo. |
| Molecular mechanism: |
ceRNA mechanism: circ_0000129 sponges miR-578 to regulate EPSTI1 expression, thereby modulating sevoflurane-mediated breast cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0000129 is up-regulated in breast cancer tissues/cells and acts as a ceRNA that sponges miR-578 to increase EPSTI1 expression. Functionally, circ_0000129 counteracts sevoflurane’s anti-tumor effects by promoting proliferation, migration and invasion and reducing apoptosis, and it partially reverses sevoflurane-suppressed tumor growth in xenografts. |
| Confidence score: |
0.7856 |