circRNA basic information
circBase ID: -
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissue; adjacent non-cancer tissue
Cell lines:

LN-229; U-138
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-23a
Biological function: suppresses glioblastoma cell invasion and migration
Molecular mechanism: inhibits miR-23a maturation (not via predicted sponge binding site); miR-23a reverses circPTK2 effects
Biological pathway or process:

migration (inhibits); invasion (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Pearson's correlation coefficient; Transfection; Transwell Assay
Clinical significance:

-
Description:

circPTK2 is down-regulated in glioblastoma tissues. Its overexpression suppresses GBM cell invasion and migration by inhibiting maturation of miR-23a, and miR-23a overexpression can reverse these inhibitory effects.
Confidence score:

0.5736
Other information
Title:

CircRNA circPTK2 Might Suppress Cancer Cell Invasion and Migration of Glioblastoma by Inhibiting miR-23a Maturation.

Journal: Neuropsychiatric disease and treatment
Published: 2021
PubMed ID: 34456566
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are not publicly available ... but available on request from the corresponding author
Code availability: -