| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-5683, hsa-miR-4779, miR-5683 |
| Biological function: |
promotes malignant progression/metastasis-associated phenotype; associated with proliferation and angiogenesis indicators via miR-5683 correlation |
| Molecular mechanism: |
predicted circRNA-miRNA interaction with hsa-miR-5683 (negative correlation in tissues); direct binding not experimentally validated |
| Biological pathway or process: |
proliferation (other); angiogenesis (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
enriched in EBVaGC CSC-derived exosomes; higher in EBVaGC patients with metastasis; detectable in serum exosomes from xenografts; potential liquid biopsy marker |
| Description: |
hsa-circRNF13 is enriched and up-regulated in EBVaGC CSC-derived exosomes and is higher in EBVaGC tissues from patients with metastasis. Its expression is negatively correlated with hsa-miR-5683 in EBVaGC tissues, supporting a potential circRNA/miRNA regulatory relationship, and it may have value as a circulating exosomal biomarker (xenograft serum exosomes). |
| Confidence score: |
0.7113 |