circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_104168
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent non-tumor liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HRAS
Associated microRNA: hsa-miR-139-5p
Biological function: May act as a ceRNA to capture hsa-miR-139-5p and may play a vital role in HCC.
Molecular mechanism: ceRNA mechanism involving hsa_circRNA_104168/hsa-miR-139-5p/HRAS
Biological pathway or process:

ceRNA regulation (other); MAPK (other); PI3K/AKT (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_104168 was up-regulated in HCC and validated by qRT-PCR. The study proposed that it may function as a ceRNA by capturing hsa-miR-139-5p and participating in a hsa_circRNA_104168/hsa-miR-139-5p/HRAS regulatory axis.
Confidence score:

0.4032
Other information
Title:

Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis.

Journal: Journal of gastroenterology and hepatology
Published: 2020
PubMed ID: 31222831
Study type:

combined bioinformatics and clinical validation study
Data availability: TCGA; GSE78520; GSE94508; GSE97332
Code availability: -