| Expression pattern: |
UP |
| Associated gene: |
TRIM13, CAPRIN1, NF-kappaB |
| Associated microRNA: |
miR-487b-5p |
| Biological function: |
promotes inflammation and AR symptoms by increasing pro-inflammatory mediators and reducing IL-2 and IFN-gamma; knockdown alleviates AR symptoms |
| Molecular mechanism: |
acts as a miRNA sponge for miR-487b-5p to de-repress TRIM13, increasing p65 phosphorylation and inflammatory cytokine expression |
| Biological pathway or process: |
inflammation (promotes); NF-kappaB (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; RNase R Treatment; Sanger Sequencing; FISH / smFISH; divergent primers PCR; Luciferase Reporter Assay; Transfection; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
hsa_circRNA_100791 could be a promising new therapeutic target for AR |
| Description: |
hsa_circRNA_100791 is up-regulated in PBMCs and nasal mucosa of allergic rhinitis patients and mainly localizes to the cytoplasm. It promotes AR-associated inflammation by sponging miR-487b-5p to increase TRIM13 expression, enhancing NF-kappaB activation and pro-inflammatory cytokine production; knockdown alleviates OVA-induced AR symptoms in mice. |
| Confidence score: |
0.8389 |