| Expression pattern: |
UP |
| Associated gene: |
BAK1, AGO2 |
| Associated microRNA: |
miR-126-3p |
| Biological function: |
inhibits trophoblast proliferation; promotes trophoblast apoptosis; exacerbates preeclampsia-like features in vivo |
| Molecular mechanism: |
Acts as an endogenous miR-126-3p sponge to upregulate BAK1 (ceRNA axis), associated with repression of mTOR and ERK1/2 signaling. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); PI3K/AKT/mTOR (inhibits); ERK (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; FISH / smFISH; IHC (Immunohistochemistry); In Vivo Animal Model; ELISA; TUNEL; H&E Staining |
| Clinical significance: |
Upregulated in preeclampsia placentas and positively correlated with severity/clinical manifestations (SBP, DBP, proteinuria). |
| Description: |
hsa_circ_0002348 is up-regulated in preeclampsia placentas and correlates with disease severity. It inhibits trophoblast proliferation and promotes trophoblast apoptosis by sponging miR-126-3p to increase BAK1, with involvement of mTOR and ERK1/2 signaling changes. |
| Confidence score: |
0.8266 |