| Expression pattern: |
UP |
| Associated gene: |
RNF38 |
| Associated microRNA: |
miR-568 |
| Biological function: |
Circ_0097009 acts as an oncogenic circRNA in HCC; its knockdown suppresses colony formation, proliferation, migration, invasion, angiogenesis and tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_0097009 sponges miR-568 to up-regulate RNF38 expression, forming the circ_0097009/miR-568/RNF38 axis in HCC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0097009/miR-568/RNF38 axis was expected to be a novel therapeutic option for HCC patients |
| Description: |
Hsa_circ_0097009/circ_0097009 is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses HCC cell proliferation, colony formation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0097009 sponges miR-568 to up-regulate RNF38, forming a circ_0097009/miR-568/RNF38 regulatory axis with potential therapeutic relevance. |
| Confidence score: |
0.8006 |