circRNA basic information
circBase ID: hsa_circ_0001175
Name: hsa_circ_YTHDF1
Synonym: circ_0001175
Host Gene: YTHDF1
Genomic location(hg19): chr20:61826924-61827836:-
Genomic location(hg38): chr20:63195572-63196484:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent tissues; lungs
Cell lines:

L02; SMMC-7721; Bel-7402; Huh-7; HepG2; Hep3B; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SNX5, Ago2
Associated microRNA: miR-130a-5p
Biological function: promotes HCC cell proliferation, migration, invasion, EMT and lung metastasis
Molecular mechanism: acts as a sponge/ceRNA for miR-130a-5p, relieving repression of SNX5
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; BrdU; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining
Clinical significance:

high expression of circ_0001175 was associated with increased TNM stage and low differentiation of tumor tissues
Description:

circ_0001175 is up-regulated in hepatocellular carcinoma and promotes proliferation, migration, invasion, EMT, and lung metastasis. Mechanistically, it sponges miR-130a-5p to increase SNX5 expression, forming a circ_0001175/miR-130a-5p/SNX5 ceRNA axis associated with more aggressive clinicopathologic features.
Confidence score:

0.763
Other information
Title:

Circ_0001175 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis by Regulating miR-130a-5p.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 33408482
Study type:

combined biological and clinical study
Data availability: -
Code availability: -