| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-298, hsa-miR-2278, hsa-miR-3154, hsa-miR-5691, hsa-miR-1304-3p, hsa-miR-6805-3p, hsa-miR-6828-3p, hsa-miR-767-3p |
| Biological function: |
May function as a competing endogenous RNA and play vital roles in BCa development; its decreased expression in serum exosomes may have value for BCa prediction. |
| Molecular mechanism: |
Predicted ceRNA/miRNA sponge mechanism; overexpression of hsa-circRNA-0005795 reduced hsa-miR-1304-3p and hsa-miR-3154 levels, supporting hsa-circRNA-0005795/hsa-miR-1304-3p and hsa-circRNA-0005795/hsa-miR-3154 interactions. |
| Biological pathway or process: |
ceRNA regulation (other); Wnt/beta-catenin (other); TGF-beta/SMAD (other); Hippo/YAP (other); PI3K/AKT/mTOR (other); other pathway/process (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
May serve as a stable exosomal biomarker for predicting BCa tumorigenesis, development and metastasis. |
| Description: |
hsa-circRNA-0005795 is down-regulated in breast cancer serum exosomes and tissues. The study proposes that it may act as an exosomal ceRNA/miRNA sponge, especially through hsa-miR-1304-3p and hsa-miR-3154 interactions, and may have biomarker value for BCa prediction. |
| Confidence score: |
0.695 |