| Expression pattern: |
DN |
| Associated gene: |
BMP2 |
| Associated microRNA: |
miR-513a-3p |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; suppresses tumor growth; suppresses metastasis |
| Molecular mechanism: |
ceRNA mechanism by sponging miR-513a-3p to regulate BMP2 expression |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
circEPHA3 is down-regulated in high-grade prostate cancer and aggressive PCa cell lines. It acts as a tumor suppressor by sponging miR-513a-3p to relieve repression of BMP2, thereby inhibiting proliferation and metastasis in vitro and in vivo. |
| Confidence score: |
0.8297 |