| Expression pattern: |
UP |
| Associated gene: |
BRD4, ABCC4 |
| Associated microRNA: |
miR-141-3p |
| Biological function: |
Promotes proliferation and migration of prostate cancer cells and accelerates prostate cancer progression. |
| Molecular mechanism: |
hsa_circ_0030568 acts as a miRNA sponge for miR-141-3p and upregulates BRD4 expression through the miR-141-3p-BRD4 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May act as a potential biomarker of PCa and a promising target for PCa treatment. |
| Description: |
hsa_circ_0030568 is up-regulated in prostate cancer cells and promotes PCa cell proliferation and migration. Mechanistically, it sponges miR-141-3p to increase BRD4 expression, thereby exacerbating PCa progression. The study proposes the circ_0030568-BRD4 axis as a potential biomarker and therapeutic target for PCa. |
| Confidence score: |
0.7615 |