circRNA basic information
circBase ID: hsa_circ_0067997
Name: hsa_circ_FNDC3B
Synonym: circ_0067997
Host Gene: FNDC3B
Genomic location(hg19): chr3:172013152-172028671:+
Genomic location(hg38): chr3:172295362-172310881:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; corresponding non-cancer tissues; tumour samples
Cell lines:

GES-1; SGC-7901; MGC-803; BGC-823; MKN28
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: XIAP, FNDC3B
Associated microRNA: miR-515-5p
Biological function: Circ_0067997 acts as an oncogene in gastric cancer, promoting GC cell viability, proliferation, colony formation, invasion, and in vivo tumor growth.
Molecular mechanism: Circ_0067997 functions through a ceRNA mechanism by directly sponging miR-515-5p, thereby relieving miR-515-5p-mediated repression of XIAP and upregulating XIAP expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; circRIP; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ_0067997 expression is associated with poor overall survival, TNM stages, and differentiation grade in GC, suggesting potential diagnostic and therapeutic value.
Description:

Hsa_circ_0067997 is up-regulated in gastric cancer tissues and cell lines and its high expression is associated with worse overall survival. Functionally, it promotes GC cell viability, colony formation, invasion, and xenograft tumor growth. Mechanistically, circ_0067997 acts as a sponge for miR-515-5p, upregulates XIAP, and drives GC progression through the circ_0067997/miR-515-5p/XIAP axis.
Confidence score:

0.7967
Other information
Title:

Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP).

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 30688097
Study type:

combined biological and clinical study
Data availability: GSE78092; GSE83521; GSE89143; GSE93541; TCGA
Code availability: -