circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: -
Host Gene: ERBB2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serum CircERBB2 is highly expressed in NSCLC patients and is associated with disease progression, larger tumor diameter, lymph node metastasis, advanced TNM stage, diagnostic value, and poor prognosis.
Molecular mechanism: The mechanism of CircERBB2 in NSCLC was not explored; the study focused on serum expression, diagnostic performance, clinicopathological correlations, and prognostic association.
Biological pathway or process:

metastasis (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis
Clinical significance:

Serum CircERBB2 has diagnostic value for NSCLC, its combined detection with CEA improves diagnostic performance, and high serum CircERBB2 expression is associated with poor prognosis.
Description:

CircERBB2 was measured in serum from NSCLC patients, benign lung disease patients, and healthy controls, and was found to be highly expressed in NSCLC. Higher serum CircERBB2 was associated with tumor diameter, lymph node metastasis, TNM stage, increased death-group levels, worse 36-month survival, and good diagnostic performance, especially when combined with CEA. The study did not investigate a molecular mechanism for CircERBB2 in NSCLC.
Confidence score:

0.4992
Other information
Title:

Diagnostic and prognostic value of serum CircERBB2 level in NSCLC and its correlation with clinicopathological features in NSCLC patients.

Journal: American journal of translational research
Published: 2023
PubMed ID: 36915755
Study type:

clinical study
Data availability: -
Code availability: -