circRNA basic information
circBase ID: hsa_circ_0001998
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:65922338-66028484:+
Genomic location(hg38): chr14:65455620-65561766:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous samples; adjacent non-cancerous samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: EPHA4, KCNA1
Associated microRNA: hsa-miR-490-5p
Biological function: Predicted to function as a hsa-miR-490-5p sponge in the gastric cancer ceRNA network.
Molecular mechanism: Predicted ceRNA mechanism involving hsa_circ_0001998, hsa-miR-490-5p, and downstream target genes including EPHA4 and KCNA1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001998 was identified as one of two differentially expressed circRNAs in the gastric cancer ceRNA network based on GEO microarray and bioinformatics analyses. The study predicted that hsa_circ_0001998 may act as a hsa-miR-490-5p sponge and regulate downstream target genes such as EPHA4 and KCNA1, but no positive RT-qPCR or functional validation was reported for this circRNA.
Confidence score:

0.1768
Other information
Title:

Comprehensive analysis of circular RNA-associated competing endogenous RNA networks and immune infiltration in gastric cancer.

Journal: Transplant immunology
Published: 2023
PubMed ID: 36773765
Study type:

bioinformatics study
Data availability: GSE83521; GSE100170; TCGA; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83521; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100170; https://portal.gdc.cancer.gov/
Code availability: -