| Expression pattern: |
UP |
| Associated gene: |
Bax, Bcl-2 |
| Associated microRNA: |
miRNA-124-3p, miR-124-3p |
| Biological function: |
CircHIPK3 aggravates myocardial I/R injury, inhibits proliferative ability, and induces apoptosis of cardiomyocytes. |
| Molecular mechanism: |
CircHIPK3 binds to miRNA-124-3p and negatively regulates miRNA-124-3p; circHIPK3 overexpression upregulates Bax and downregulates Bcl-2, promoting cardiomyocyte apoptosis. |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
CircHIPK3 may serve as a potential therapeutic target for I/R injury. |
| Description: |
This study found that circHIPK3 is up-regulated in an in vitro HCM cell model of myocardial I/R injury. CircHIPK3 aggravates myocardial I/R injury by binding to and inhibiting miRNA-124-3p, thereby suppressing cardiomyocyte proliferation and promoting apoptosis with altered Bax and Bcl-2 expression. The authors propose circHIPK3 as a potential therapeutic target for I/R injury. |
| Confidence score: |
0.5554 |