| Expression pattern: |
UP |
| Associated gene: |
HMGA1, MMP9 |
| Associated microRNA: |
hsa-let-7a-5p, hsa-let-7c-5p, hsa-miR-26a-5p, hsa-miR-125b-5p, hsa-miR-195-5p, hsa-miR-497-5p |
| Biological function: |
may promote tumor invasion |
| Molecular mechanism: |
predicted ceRNA/miRNA sponge competing for shared miRNAs with HMGA1 to increase HMGA1 expression |
| Biological pathway or process: |
invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
may be potential diagnostic biomarkers for HCC |
| Description: |
cZRANB1 (hsa_circ_0000268) is up-regulated in HCC tumor tissues and is also higher in HCC patient blood exosomes. The study predicts that it may act as a ceRNA/miRNA sponge (e.g., for let-7 family and miR-125b-5p/miR-195-5p/miR-497-5p) to increase HMGA1 expression and thereby promote tumor invasion. |
| Confidence score: |
0.1768 |