circRNA basic information
circBase ID: hsa_circ_0004650
Name: -
Synonym: hsacirc_004413
Host Gene: -
Genomic location(hg19): chr12:47497895-47501947:+
Genomic location(hg38): chr12:47104112-47108164:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SGC-7901; SGC-7901-5-Fu; MKN-45
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-145-5p
Biological function: Promotes proliferation and 5-Fu chemoresistance; inhibits apoptosis and necrosis in 5-Fu-resistant gastric cancer cells.
Molecular mechanism: Acts as a competing endogenous RNA (miRNA sponge) to adsorb miR-145-5p, reducing miR-145-5p activity and thereby inhibiting apoptosis and promoting 5-Fu resistance.
Biological pathway or process:

apoptosis (inhibits); proliferation (promotes); chemoresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; CCK8; In Vivo Animal Model
Clinical significance:

-
Description:

hsacirc_004413 (hsa_circ_0004650) is up-regulated in 5-Fu-resistant gastric cancer cells and promotes proliferation and 5-Fu chemoresistance. Its knockdown increases apoptosis/necrosis and restores 5-Fu sensitivity, likely by sponging miR-145-5p.
Confidence score:

0.4469
Other information
Title:

The regulation of hsacirc_004413 promotes proliferation and drug resistance of gastric cancer cells by acting as a competing endogenous RNA for miR-145-5p.

Journal: PeerJ
Published: 2022
PubMed ID: 35415017
Study type:

biological research
Data availability: Ensembl: SourceGene: ; circBase_ID: hsa_circ_0004650; Dryad: .
Code availability: -